The Flanders family is the standard set of neighbors that make everyone else look bad, especially the Simpsons. Their super-religious outlook on life often leads to annoyance of others, especially. Homer often tries create troubles for the Flanders' in spite of their holy nature. Because of her kind heartedness, is usually the one left defending The Flanders family.
The Flanders basically represent the family of do-gooders that every community has. The kind of people that no one can hate, because they haven't done anything wrong. Yet many people still resent them unconsciously, because they always seem to be acting superior to everyone else. Although the Flanders have no malintent to make others feel bad, it is more of an issue of always being he way they are rather than trying to shun others.